Prediction of Clopidogrel Low Responders by a Rapid CYP2C19 Activity Test

Effects of CYP2C19 genotype on outcomes of clopidogrel treatment.

BACKGROUND It has been suggested that clopidogrel may be less effective in reducing the rate of cardiovascular events among persons who are carriers of loss-of-function CYP2C19 alleles that are associated with reduced conversion of clopidogrel to its active metabolite. METHODS We genotyped patients from two large, randomized trials that showed that clopidogrel, as compared with placebo, reduc...

Feasibility of a Microarray-Based Point-of-Care CYP2C19 Genotyping Test for Predicting Clopidogrel On-Treatment Platelet Reactivity

Clopidogrel is a prodrug which is converted into active metabolite by cytochrome P450 isoenzyme, CYP2C19. Numerous polymorphisms of CYP2C19 are reported, and a strong link exists between loss-of-function (LOF) or gain-of-function polymorphisms, clopidogrel metabolism, and clinical outcome. Hence, a fully automated point-of-care CYP2C19 genotyping assay is more likely to bring personalized antip...

Shelf Life Prediction of Infant Formula by Using Rancidity Test

Infant formula has a fatty acid composition that meets the needs of the neonates for unsaturated fatty acids.These fatty acids are of major importance during this period of life in which the brain and retina are developing, and will therefore have an influence upon visual acuity and learning abilities. Oxygen reacts readily with unsaturated fatty acids, so that every time these compounds are ha...

Comment on “Association between CYP2C19 and ABCB1 polymorphisms and clopidogrel resistance in clopidogrel-treated Chinese patients”

Clopidogrel and CYP2C19 testing: ready for clinical prime time?

Effective platelet inhibition has become a cornerstone in the management of patients with acute coronary syndromes (ACSs). The addition of clopidogrel, a blocker of the ADP platelet receptor, to aspirin therapy significantly reduces major cardiovascular events in ACS patients and reduces the frequency of percutaneous coronary intervention (PCI) with stent implantation. As PCI became the dominan...